Longer trinucleotide repeats of androgen receptor are associated with higher testosterone and low oxytocin levels in diabetic premature ejaculatory dysfunction patients

Table 1 Baseline demographics, Clinical and hormonal characteristics of diabetic premature ejaculatory dysfunction patients and normal study cohort

Variables	Subjects with PE + DM (n = 250) Mean ± SD	Control Subjects (n = 150) Mean ± SD	ρ*
Clinical Parameters
(CAG)n repeats	22.0 ± 5.34	21.4 ± 6.3	NS
(GGC)n repeats	22.01 ± 4.36	22.0 ± 7.2	NS
Age (years)	45.0 ± 10.1	45.3 ± 7.5	NS
BMI (kg/m²)	31.5 ± 4.0	29.43 ± 3.99	NS
Blood collection time (8–10 AM)/30 mint	8.79 ± 2.59	9.29 ± 6.34	NS
HbA_1C (%)	7.01 ± 2.41	3.85 ± 1.05	< 0.001
Diabetes duration (years)	8.25 ± 4.59	–	–
Hormonal Assays
Oxytocin (pg/ml)	87.9 ± 25.2	69.4 ± 23.6	< 0.001
Prolactin (ng/ml)	5.05 ± 2.31	7.1 ± 1.62	< 0.001
TSH (mIU/L)	1.56 ± 2.1	3.19 ± 1.6	< 0.001
Total Testosterone (ng/ml)	4.76 ± 1.52	3.63 ± 1.26	< 0.001
Premature Ejaculation Assessments
PEDT	18.7 ± 3.81	7.21 ± 3.56	< 0.001
Self-estimated IELT (s)	121 ± 7.69	314.8 ± 28.36	< 0.001
Depression Assessments
BDI-II	48 ± 9.40	8.7 ± 3.12	< 0.001
Sexual Assessments
IIEF-15	44.3 ± 9.60	49.3 ± 2.8	NS

PE: Premature Ejaculatory dysfunction; DM: Diabetes mellitus type II; NS Not significant; BMI Body mass index; TSH Thyroid stimulating hormone; PEDT Premature ejaculation diagnostic tool; BDI-II Beck’s Depression Inventory-II; IELT Intravaginal ejaculatory latency time; IIEF-15 International index of Erectile Dysfunction-15
Data have shown as mean ± SD. p* Mann-Whitney; p < 0.05 was considered statistically significant

ISSN: 2051-4190