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Table 1 Investigations focused on the diagnostic value of PLCζ in human sperm

From: “This is where it all started” – the pivotal role of PLCζ within the sophisticated process of mammalian reproduction: a systemic review

Reference

Population

PLCζ related Findings

Yoon et al., 2008 [58]

Recurrent failed ICSI

Absent

Grasa et al., 2008 [37]

Fertile participants

Variable localization in uncapacitated and capacitated sperm

Heytens et al., 2009 [32]

Infertile patients

Low expression or abnormal forms

Yelumalai et al., 2015 [57]

Infertile patients

Low expression and specific localization patterns

Escoffier et al., 2015 [56]

Globozoospermia

Absent or extremely reduced expression