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Table 1 Mammalian sperm functions regulated by some selected oestrogens (17β-estradiol, catechol oestrogens, diethylstilbestrol, estrone, estriol, ethynylestradiol, genistein)

From: Interactions between oestrogen and 1α,25(OH)2-vitamin D3 signalling and their roles in spermatogenesis and spermatozoa functions

Molecule Event Species Effect Reference
17β-estradiol (E2) Viability Human No effect [89]
ROS production Human No effect [89]
DNA integrity Human -/no effect [89, 90]
Motility Human Golden hamster Stallion +/no effect + - [14, 89, 9195]
Capacitation Human, mouse, boar bovine + No effect [14, 95, 98100], [102] a [103]
Acrosome reaction Human Boar Mouse Bovine, stallion +/no effect + +/- No effect [92, 95, 98100], [102] a [103]
Progesterone stimulated calcium and induced acrosome reaction Human - [3]
Fertilizing ability Mouse + [99]
Lipolytic effect Human + [14]
Glucose metabolism and insulin secretion Human + [14]
Catechol oestrogens (2OHE2, 4OHE2) Viability Human -/no effect [89]
ROS production Human + [89]
DNA integrity Human -/no effect [89]
Motility Human - [89]
Diethylstilbestrol (DES) Viability Human No effect [89]
ROS production Human + [89]
DNA integrity Human -/No effect [89, 90]
Estrone (E1,) Estriol (E3), Ethynylestradiol (EE2) Capacitation Boar, mouse + [98, 101]
Acrosome reaction Boar Mouse + - [98, 101]
Genistein Viability Human No effect [89]
ROS production Human + [89]
DNA integrity Human - [90]
Capacitation Human, mouse, boar, bovine + [99, 100], [102] a [103]
Acrosome reaction Human, mouse, boar Bovine + No effect [99, 100], [102] a [103]
Fertilizing ability Mouse + [99]
  1. +: positive effect, -: negative effect and +/-: positive and negative effect
  2. a Effects dependent of the time and the concentration
  3. ROS reactive oxygen species
  4. DNA deoxyribonucleic acid