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Table 1 List of miRNAs related to male idiopathic fertility disorders and their putative functions

From: Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility

Patients Samples miRNA expression hsa-miRNA Putative functions
Fertile (controls) Spermatozoa - miR-34b-3p [46] E2F-pRb regulation
- miR-132-3p [46] Cell cycle progression
- miR-191-3p [46] Sperm differentiation
- miR-30b-5p, miR-30c-5p, miR-375, miR-19b-3p, miR-200c-3p [46] Cancer and aging
- miR-891a, miR-1233-3p [46] Unknown biological function
NOA Testis tissue Down miR-1, miR-181a, miR-221, miR-9*, miR-371, miR-372, miR-373 [49] Development of human testis germ cell tumors
Idiopathic infertility (NOA, Asthenozoospermia, Oligozoospermia, Astheno-Oligozoospermia) Seminal plasma, Spermatozoa, Extracellular Microvesicles, Up mir-429 [36, 48, 51, 52] Spermatogenesis
miR-1275 [47, 53]
Spermatozoa, Extracellular Microvesicles Down miR-15b [47, 48, 51, 53]  
Spermatozoa, Seminal plasma Up miR-141 [36, 48, 51] Embryonic development
Spermatozoa Up miR-19b [47, 54], miR-483-5p [47, 53] Unknown
Spermatozoa Down miR-19a [48, 53], miR-1973 [48, 51] Unknown
Spermatozoa, Extracellular Microvesicles miR-28-5p [47, 53]
NOA Seminal plasma, Spermatozoa, Testis tissue Up miR-429 [36, 48, 52] Spermatogenesis
Spermatozoa Down miR-34* [52], miR-34c-5p [48, 52, 55], miR-122 [48, 52, 55]
Asthenozoospermia Spermatozoa Up miR-27a [47, 57] Signaling pathway
Spermatozoa Up miR-548b-5p, miR548c-5p, miR-548d-5p [47]
Spermatozoa Down miR-34b-3p [47, 51] Spermatogenesis
Spermatozoa Down miR-520 h, miR-520d-3p [47] Embryonic development
Oligo-Astheno-Zoospermia Spermatozoa Down miR-15a, miR-15b, miR-30, miR-34b, miR-34c-5p, miR-193-5p [51, 53] Spermatogenesis
Oligozoospermia and Teratozoospermia Spermatozoa Down miR-151-5p [47] Aging
miR-935, miR-125a-3p [47] Cell cycle and chromatin modification
miR-132-5p, miR-320b, miR-195-5p [47] Cellular component morphogenesis and cell morphogenesis