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Table 4 Effects of increase in testis temperature (testes in the superficial inguinal pouch) on sperm number in men

From: Hormonal, chemical and thermal inhibition of spermatogenesis: contribution of French teams to international data with the aim of developing male contraception in France

Authors

Heating

Nb a

Effect on sperm number

Method

Daily duration

Frequency

 

During heating

After heating

Period

w b

Mean

value

Start

w

Max.

value

Mieusset et al. 1985 [92]

Testes in the superficial inguinal pouch; special underwear c

SAT d +2 °C

15 h

Every day for 6 months

14

w 4

w 12

w 25

54% e

29%

13%

w8

w16

w29

w37

73% f

89%

133%

159%

Every day for 12 months

8

w 25 to w 52

from 13 to 5%

w10

w16

w37

60%

72%

129%

Mieusset et al. 1987 [93]

Tech 1: same as previous [92]

SAT +2 °C

15 h

Every day for 6–24 months

13

9

w 18

w 36

w 45

58%

28%

14%

8%

w9

w18

w36

40%

80%

120%

Tech 2 = Tech 1 + reinforcement of the hole

SAT +2 °C

Every day for 6–24 months

6

w 9

w 18

w 36

w 45

28%

3.5%

4.5%

<1%

w9

w18

w36

10%

60%

100%

Shafik 1991 [83]

Testes in the superficial inguinal pouch (stitch suspension technique) SAT +2 °C

Day and night

Every day for 12 months

15

SC g > 40

w 13:

1 < SC i >10 in 2/15

11 < SC > 20 in 13/15

w 26:

SC = 0 in 2/15

0 < SC > 1 in 5/15

2 < SC > 10 in 8/15

NR h

NC i

w 26:

SC > 40 in 15/15

Ball suspension

SAT +2 °C

Every day for 12 months

13

SC > 40

w 13:

1 < SC > 10 in 2/13

11 < SC > 20 in 11/13

w 26:

SC = 0 in 2/13

0 < SC > 1 in 5/13

2 < SC > 10 in 6/13

NR

NC

w 26:

SC > 40 in 13/13

Shafik 1992 [94]

Suspensory sling of polyester

fabric j

SAT +2 °C

Day and night

Every day for 12 months

14

SC > 40

w 13: SC < 1 in 4/14

2 < SC > 10 in 10/14

w 26:

SC = 0 in 14/14

w 5–9

NC

w 26:

SC > 40 in 14/14

Moeloek 1995 [95]

Suspensory sling as used by

Shafik 1992 [94]

Day and night

Every day for 24 weeks

10

SC > 20

w 12: SC < 20 in 4/10

w 24:

SC < 20 in 10/10

SC < 10 in 3/10

NR

NR

Ahmad et al. 2012 [96]

Tech 3: Tech 2 [93] + improved material SAT +2 °C

15 h

Every day for 17 weeks

5

w 1

w 3

w 5

w 7

w 10

78%

92%

16%

3.5%

0.5%

w5

w7

w10

2.5%

22%

124%

  1. Legend: a number of men; b weeks; c testes pushed up and maintained in the superficial inguinal pouch by exteriorization of penis and scrotum through a hole in specially designed underwear; d scrotal achieved temperature; e mean value of total sperm number/initial total sperm number (%); f maximal value of total sperm number/initial total sperm number (%); g sperm count in million/mL; h NR not reported; i NC not calculable; j with penis uncovered and testes elevated towards the abdomen