Table 2 Published effects of one or several doses of 131I on sperm parameters and serum FSH levels
From: Sperm DNA fragmentation after radioiodine treatment for differentiated thyroid cancer
Authors | Number of patients | Dose of 131I (mCi) | Time after 131I (months) | FSH serum concentration (IU/l) | Sperm parameters |
|---|---|---|---|---|---|
0 | 32 | azoospermia | |||
Handelsman et al., 1980 [17] | 1 | 350 | 5 | 16 | |
9 | 18 | ||||
Handelsman and Turtle, 1983 [5] | 5 7 | 223 ± 53 1 dose ≤ 100 multiple doses ≥ 100 | median 12 (1–42) | no elevation ↑ | 6 men performed sperm analysis: 2 azoospermic (doses 400 and 350 mCi)4: 11 × 106 ≤ SC ≤ 32 × 106 |
Pacini et al., 1994 [19] | 40 | 30–100 | 6–12 | 12.3 ± 7.5 | 9 men performed sperm analysis: 8 have minor to evident reduced sperm motility |
24 | 101–200 | 14.2 ± 9.6 | |||
22 | 201–400 | 15.4 ± 7.4 | |||
8 | 401–600 | 18.9 ± 10.6 | |||
9 | >600 | 27.7 ± 15.1 | |||
4 | several doses | ↑ after each dose-remained elevated after 60 months | |||
Wichers et al., 2000 [6] | 11 | 150–700 | 3 | 17 | no data |
18 | 6 | 21.3 ± 2.4 | |||
22 | 12 | 13 | |||
18 | 18 | 7.4 ± 1.3 | |||
Hyer et al., 2002 [18] | 7 | 81 | 1 | 11–24 | no data |
3 | 8–22 | ||||
6 | 3–17 | ||||
9 | 7–10 | ||||
7 | 2nd dose (dose not specified) | ↑ FSH after 2nd dose back to normal by 12 months | |||
Rosario et al., 2006 [7] | 52 | 100–150 | 6 | 24.2 ± 3.2 | oligozoospermia in 66% patients with elevated FSH 18 months after treatment |
12 | 9.5 ± 1.9 | ||||
18 | 5.9 ± 1.9 |