Peroxiredoxins: hidden players in the antioxidant defence of human spermatozoa

Table 1 Distribution of the known antioxidant enzymes in subcellular compartment of human spermatozoa

*Plasma membrane*	*Cytosol*	*Acrosome*	*Nucleus*	*Equatorial segment*	*Midpiece*	*Flagellum*
PRDX2	PRDX4 (p27)	PRDX2	PRDX1	PRDX1	PRDX2	PRDX1
PRDX4 (p27)	PRDX6	PRDX4 (p27, p31)	PRDX2	PRDX5	PRDX3	PRDX2
PRDX5	Cu/ZnSOD	PRDX5	PRDX3	PRDX6	PRDX5	PRDX3
PRDX6	TRX1	PRDX6	PRDX4 (p27, p31)	TRX1	PRDX6	PRDX6
	TRD1	SPTRX1	PRDX5		MnSOD	SPTRX1
	TGR	SPRTX2	PRDX6		GPX4 (inactive)	SPTRX2
		TGR	GPX4 (inactive?)		TRX2	TRX-like 2
			SPRTX1		SPTRX1	TGR
			SPTRX2		SPTRX2
			TRX1		TRD2
			TGR		TGR

References for enzymes listed above: PRDXs [85] and Figure 2, Cu/ZnSOD and MnSOD [87], GPX4 [88, 89], SPTRX1 [90–92], SPTRX2 [90, 91, 93], TRX2 and TRX-like-2 [91, 94], TRD1, TRD2 and TGR [90, 91].

ISSN: 2051-4190