A prospective study in male recipients of kidney transplantation reveals divergent patterns for inhibin B and testosterone secretions

Table 1 Clinical, biological and hormonal status of donors and patients

	A–healthy controls (n = 46)	B–graft recipients before transplantation (n = 53)	C–graft recipients after transplantation (n = 53)	p value
				B vs A	B vs C	C vs A
Age (years)^a	36.8 (5.3)	37.0 (8.0)	–	0.73^d
BMI ^a	–	22.6 (4.0)	23.4 (4.1)		0.33
HD duration (months)^a	–	35.7 (28.6)	–
Creatinine (μmol/L)^a	–	846.0 (221.0)	141.0 (79.0)		<0.001
GFR (mL/min)^b, LH (IU/L)			57.1 (17.2)
mean, (SD)	3.3 (1.3)	8.9 (6.5)	6.7 (5.0)	<0.001	<0.001	<0.001
median, (5^th – 95^th percentile)	3.1 (1.5–5.8)	6.3 (3.1–24.8)	5.1 (2.0–16.4)
value > 8 UI/L^c, (%)	0 (0.0)	19 (36.5)	13 (24.5)
missing data^c, (%)	1 (2.2)	1 (1.9)	0 (0.0)
FSH (IU/L)
mean, (SD)	3.7 (1.7)	7.7 (7.6)	11.3 (8.2)	0.001	<0.001	<0.001
median, (5^th–95^th percentile)	3.3 (1.4–7.0)	4.9 (1.6–27.5)	9.7 (2.0–29.1)
value > 7 UI/L^c, (%)	1 (2.2)	19 (35.8)	34 (65.4)
missing data^c, (%)	1 (2.2)	0 (0.0)	1 (1.9)
Testosterone (ng/dL)
mean (SD)	512 (156)	447 (213)	398 (151)	0.12	0.12	<0.001
median (5^th–95^th percentile)	522 (261–800)	432 (171–811)	371 (190–618)
value < 288 ng/dL^c, (%)	2 (5.2)	12 (22.6)	13 (24.5)
missing data^c (%)	8 (17)	5 (9.4)	3 (5.2)
Inhibin B (pg/mL)
mean (SD)	149 (71)	145 (102)	93.6 (79.8)	0.48	<0.001	<0.001
median (5^th–95^th percentile)	137 (56–309)	127 (14–348)	68 (14–280)
value < 80 pg/mL^c, (%)	7 (15.2)	12 (27.9)	25 (47.2)
missing data^c, (%)	0 (0.0)	10 (18.9)	8 (15.1)

Data were collected from 46 healthy semen donors and 53 male recipients before (T₀) and at 6 months (T₁₈₀) after a kidney transplant.
^aMean (SD), ^bglomerular filtration rate using the MDRD formula [28], ^cnumber of events, ^dstatistical significance is set at p < 0.05.

ISSN: 2051-4190