Which inflammatory marker, between systemic immune-inflammation index and neutrophil to eosinophil ratio, is associated with Peyronie’s disease and are there any implications for a better understanding of its mechanisms?

Table 1 Clinical and laboratory data of the two groups

Variables	Peyronie’s disease n 49	Controls n 50	p
Age (years, mean ± SD) a	61.4 ± 9.8	60.2 ± 8.1	0.48
BMI (mean ± SD) a	26.4 ± 3	25.6 ± 2.3	0.15
Normoweight/Overweight/Obese (n) c	15/27/7	20/28/2	0.17
T2DM (yes/no, n) c	7/42	3/47	0.18
Hypertension (yes/no, n) c	28/21	17/33	0.017
Alcohol consumption (yes/no, n) c	12/37	16/34	0.50
Exercise (yes/no, n) c	29/20	20/30	0.07
Fasting Plasma Glucose (mg/mL, median + IQR) b	101 (85–115)	87 (77–98)	0.0088
Hyper-cholesterolemia (> 200 mg/dL, n) c	25/24	7/43	0.0001
Total Cholesterol (mg/dL, median + IQR) b	187 (162–203)	159 (136–192)	0.0018
HDL-cholesterol (mg/dL, median + IQR) b	45 (35–59)	40.5 (32–51)	0.053
LDL-cholesterol (mg/dL, median + IQR) b	95 (85–131)	89.7 (61.8–131.6)	0.11
Creatinine (mg/dL, median + IQR) b	0.9 (0.8–1.3)	0.975 (0.82–1.16)	0.08
INR (median + IQR) b	0.94 (0.92–0.95)	1.01 (0.97–1.08)	0.0001
SII b	529 (404.5–846.7)	498.4 (296.5–776.8)	0.38
NER b	32.5 (18–62.8)	17.3 (9.38–34.5)	0.0021
ENR b	0.030 (0.016–0.055)	0.036 (0.03–0.10)	0.0021

BMI body mass index, ENR eosinophil to neutrophil ratio, HDL high density lipoprotein, INR International Normalized Ratio, IQR interquartile range, LDL low density lipoprotein, n number, NER neutrophil to eosinophil ratio, p significance, SD standard deviation, SII systemic immune-inflammation index, T2DM type 2 diabetes mellitus, The symbol a indicates that the for evaluating the difference between means was used the independent, while difference in medians was assessed by the Wilcoxon rank-sum test (Mann-Whitney test), and was indicated by the symbol b. The two-way table with measures of association, calculating the Fisher’s exact, was indicate with the symbol c

ISSN: 2051-4190