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Table 3 Gene expression profiles following GnRHa treatment in HIR samples, compared to LIR

From: Epigenetics, cryptorchidism, and infertility

ENTREZ ID

Symbol

Gene name

logFC

logCPM

F

P-value

FDR

7403

KDM6A

Lysine (K)-specific demethylase 6A

-0.5239903

6.59858773

6.38593755

0.02

0.05602502

80312

TET1

Tet methylcytosine dioxygenase 1

-0.4556459

6.53997279

5.50105813

0.03

0.0726449

5926

ARID4A

AT-rich interactive domain 4A (RBP1-like)

-0.3942475

6.06506301

5.99526693

0.02

0.06260994

84159

ARID5B

AT-rich interactive domain 5B (MRF1-like)

-0.3282121

7.22882911

3.85285411

0.06

0.12618016

546

ATRX

Alpha thalassemia/mental retardation syndrome X-linked

-0.5050769

8.25041463

6.34325962

0.02

0.05671205

1788

DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha

-0.0408974

6.88450078

0.06435984

0.8

0.85889447

80314

EPC1

Enhancer of polycomb homolog 1 (Drosophila)

-0.4605667

6.37488169

7.09477148

0.02

0.04648734

3065

HDAC1

Histone deacetylase 1

-0.5318288

5.95514142

8.22826388

0.01

0.03546156

3066

HDAC2

Histone deacetylase 2

-0.6653504

6.56382014

12.470366

0.002

0.01557976

8841

HDAC3

Histone deacetylase 3

-0.2571251

5.35332599

2.24973919

0.15

0.23971303

55869

HDAC8

Histone deacetylase 8

-0.2757605

4.85618247

2.33455755

0.14

0.2308183

54891

INO80D

INO80 complex subunit D

-0.3696509

7.20095059

3.60611671

0.07

0.13834289

9682

KDM4A

Lysine (K)-specific demethylase 4A

-0.1773816

6.68355751

1.19093318

0.29

0.39899092

55904

KMT2E

Lysine (K)-specific methyltransferase 2E

-0.4299399

7.83891728

5.28127838

0.03

0.07790183

55193

PBRM1

Polybromo 1

-0.4968359

7.68461279

6.46367699

0.02

0.05490724

3275

PRMT2

Protein arginine methyltransferase 2

-0.4684083

7.55307237

5.8652164

0.02

0.06521626

80854

SETD7

SET domain containing (lysine methyltransferase) 7

-0.492024

7.03746884

6.5386345

0.02

0.05387161

6594

SMARCA1

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 1

-0.5604377

8.284278

7.53565514

0.01

0.0417173

6595

SMARCA2

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2

-0.4126955

7.70083684

5.32522555

0.03

0.07678037

23270

TSPYL4

TSPY-like 4

-0.1915808

5.42985126

1.23077045

0.28

0.39031165

196528

ARID2

AT-rich interactive domain 2 (ARID, RFX-like)

-0.5031263

7.50723586

6.38425394

0.02

0.05604618

55870

ASH1L

Ash1 (absent, small, or homeotic)-like (Drosophila)

-0.4354006

8.69924223

5.4008474

0.03

0.07498705

29994

BAZ2B

Bromodomain adjacent to zinc finger domain, 2B

-0.5080609

8.74963518

6.55737462

0.02

0.053584

10389

SCML2

Sex comb on midleg-like 2 (Drosophila)

-0.4213024

6.46964321

3.87372573

0.06

0.12519553

29072

SETD2

SET domain containing 2

-0.4934595

8.21462096

6.92834399

0.02

0.04846706

1787

TRDMT1

tRNA aspartic acid methyltransferase 1

-0.2411989

5.25399927

1.48746291

0.2

0.34221114

  1. RNA-Seq data are indicated for biopsies from high/low infertility risk (HIR/LIR) patients and samples with/without GnRH treatment. RNA levels (reads per kilobase and million, RPKM), log2 fold-changes (log2FC), and false discovery rates (FDRs) are given
  2. n.s. not significant, Lc Leydig cell, Sc Sertoli cell, Sptg spermatogonium, Sptc spermatocyte, Sptd spermatid