Table 1 Gene expression profiles in testicular cells
Gene symbol | HIR/LIR (RPKM) | log2FC/FDR | Molecular function | Testicular cell type expressing mRNA [9] |
|---|---|---|---|---|
Class 1: Leydig and/or Sertoli cells | ||||
KDM6A | 17.9/16.5 | 0.2/0.01 | Histone (lysine) demethylase | Lc/Sc |
TET1 | 11.4/9.7 | 0.33/0.001 | Functional demethylation | Lc |
Class 2: Testicular cells | ||||
ARID4A | 12.5/9.0 | 0.48/0.03 | HDAC bridging molecule | Lc/Sc/Sptg/Sptc |
ARID5B | 19.8/17.8 | 0.35/0.004 | Histone demethylase | Lc/Sc/Sptg |
ATRX | 30.1/27.9 | 0.26/0.01 | Methyltransferase | Lc/Sc/Sptg |
DNMT3A | 21.7/17.6 | 0.30/0.007 | Methyltransferase | LC/Sc/Sptg |
EPC1 | 20.7/17.9 | 0.29/0.004 | Histone acetyltransferase | Lc/Sptg |
HDAC1 | 18.4/17.5 | n.s | Deacetylase | Lc/Sc/Sptg/Sptc |
HDAC2 | 11.2/13.8 | -0.28/0.03 | Deacetylase | Lc/Sc/Sptg/Sptcs |
HDAC3 | 17.4/17.8 | n.s | Deacetylase | Lc/Sc/Sptg |
HDAC8 | 7.4/6.4 | 0.27/0.02 | Histone decrotonylase | Lc/Sc/Sptg |
INO80D | 11.1/10.3 | 0.24/0.02 | Chromatin remodeling | Lc/Sc/Sptg |
KDM4A | 23.1/21.0 | 0.2/0.01 | Histone demethylase | Lc/Sc/Sptg |
KMT2E | 35.6/30.7 | 0.29/0.01 | Methyltransferase | Lc/Sc/Sptg |
PBRM1 | 25.3/22.0 | 0.19/0.02 | Chromatin remodeling | Lc/Sc/Sptg/Sptc |
PRMT2 | 25.6/21.6 | 0.2/0.02 | Arginine methyltransferase | Lc/Sc/Sptg |
SETD7 | 18.7/17.7 | 0.22/0.047 | Methyltransferase | Lc/Sc/Sptg |
SMARCA1 | 81.8/78.2 | 0.20/0.014 | Chromatin regulator | Lc/Sc/Sptg |
SMARCA2 | 31.4/31.2 | 0.31/0.014 | Chromatin regulator | Lc/Sc/Sptg |
TSPYL4 | 11.8/9.4 | 0.32/0.01 | Chromatin binding | Lc/Sc/Sptg/Sptc |
Class 3: Germ cells | ||||
ARID2 | 18.4/16.4 | 0.23/0.02 | Chromatin remodeling | Sptd/Sptc |
ASH1L | 38.8/36.8 | 0.22/0.01 | Methyltransferase | Sptg/Sptc |
BAZ2B | 42.5/38.4 | 0.3/0.009 | Chromatin remodeling | Sptc/Sptd |
SCML2 | 21.8/19.9 | 0.25/0.005 | Transcriptional repressor | Sptg/Sptc |
SETD2 | 34.8/33.2 | 0.19/0.02 | Methyltransferase | Sptg/Sptc |
TRDMT1 | 4.7/3.9 | 0.37/0.004 | Methyltransferase | Sptc |