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Traitements anticancereux et spermatogenese. Moyens de protection

Antineoplasic treatments and spermatogenesis. Means of protection

Andrologie volume 2, pages 97–99 (1992)Cite this article

Abstract

A litterature review reports the spermatotoxicity of the different antineoplasic therapies. Recovery of spermatogenesis after completion of most toxic treatments and its delay are individually unforeseen. Pregnancies have occured after treatment with very low sperm counts. These pregnancies ask the question of mutagenicity of antineoplasic treatments. The means of protection seem presently very poor.

Resume

Une revue de la littérature fait le point de la spermatotoxicité des différentes thérapeutiques anticancéreuses. Après les traitements réputés stérilisants, la récupération de la fonction gamétogénétique et son délai s’avèrent imprévisibles au plan individuel. Des grossesses ont été obtenues après traitement anticancéreux avec des chiffres de numération spermatique très bas. Celles-ci posent le problème de la mutagénicité des thérapeutiques anticancéreuses. Les moyens de protection s’avèrent actuellement limités.

References

  1. - Bonnadonna G., Santoro A., Viviani S., Lombardi C., Ragni G. Gonadal damage in Hodgkin’s disease from cancer chemotherapeutic regimens. Arch. Toxicol., 1984,sup7:140

    Google Scholar 

  2. - Chapman R.M., Sutcliffe S.B., Rees L.H., Edwards C.R.W., Malpas J.S. Cyclical combination chemotherapy and gonadal function. Lancet, 1979,i:285

    Article  Google Scholar 

  3. - Chapman R.M., Sutcliffe S.B., Crosby W.H. Reproductive potential after treatment for Hodgkin’s disease. N.Eng.J.Med., 1981,305:890

    Article  Google Scholar 

  4. - Da Cuhna M.F., Meistrich M.L., Fuller L.M., Cundiff J.H., Hagemeister F.B., Velasquez W.S., Mc Laughlin P., Riggs S.A., Cabanillas F.F., Salvador P.G. Recovery of spermatogenesis after treatment for Hodgkin’s disease: limiting dose of Mopp chemotherapy. J.Clin.Oncol., 1984,2:571.

    Google Scholar 

  5. - Damewwod M.D., Grochow L.B. Prospects for fertility after chemotherapy or radiation for neoplastic disease. Fertil.Steril., 1986,4:443

    Google Scholar 

  6. - Friedmann N.M., Plymate S.R. Leydig cell dysfunction and gynecomastia in adult males treated with alkylating agents. Clin.Endoc., 1980, 12:553

    Article  Google Scholar 

  7. - Glode L.M., Robinson J., Gould S.F. Protection from cyclophosphamide induced testicular damage with an analog of gonadotrophin releasing hormone. Lancet, 1981,i:1132

    Article  Google Scholar 

  8. - Hahn E.W., Feingold S.M., Niscel L. Aspermia and recovery of spermatogenesis in cancer patients following incidental gonadal irradiation during treatment: a progress report. Radiology 1976,119:223

    PubMed  CAS  Google Scholar 

  9. - Hahn E.W., Feingold S.M., Simpson L., Batata M. Recovery from aspermia induced by low dose radiation in seminoma patients. Cancer, 1982,50:337

    Article  PubMed  CAS  Google Scholar 

  10. - Hsu E.W., Folami A.O., Bain J., Rance C.P. Gonadal function in males treated with cyclophosphamide for neoplastic syndrome. Fertil.Steril. 1979,31:173

    PubMed  CAS  Google Scholar 

  11. - Jackson H., Hass C.A., Sooby D., Marschke C.H. The gonadal exposure of boys and young men treated with inverted Y fields. Radiology 1970,96:181

    PubMed  CAS  Google Scholar 

  12. - Kreuser E.D., Hetzel W.D., Heit W., Hoelzer D., Eurrle E., Xiros N., Heimpel H. Reproductive and endocrine function gonadal functions in adults following multidrug chemotherapy for acute lymphoblastic or undifferentiated leukemia. J.Clin.Oncol., 1988,6:588

    PubMed  CAS  Google Scholar 

  13. - Marmor D. Influence de la maladie de Hodgkin sur les fonctions reproductrices. In: Progrès en Hématologie. Hoerni B., Simon G, Gisselbrech C. ed. Doin Paris, 1985: 165

    Google Scholar 

  14. - Meistrich M.L. Relationship between spermatogonial stem cell survival and testis function after cytotoxic therapy. Br.J.Cancer, 1986,53:89

    Google Scholar 

  15. - Morris I.D., Shalet S.M. Protection of gonadal function from cytotoxic chemotherapy and irradiation. Baill.Clin.Endoc.Metab., 1990,4:97

    Article  CAS  Google Scholar 

  16. - Pontonnier S., Navratil H. Stérilité masculine et cancer du testicule. J.Urol., 1984,90:308

    Google Scholar 

  17. - Richter P., Calamera J.C., Morgenfield M.C., Kierszenbaum A.L., Lavieri J.C., Mancini R.E. Effects of chlorambucil on spermatogenesis in the human with malignant lymphoma. Cancer, 1970,25:1026

    Article  PubMed  CAS  Google Scholar 

  18. - Rowley M.J., Leach D.R., Warner G.A., Heller C.G. Effects of graded doses of ionizing radiations on the human testis. Radiat.Res., 1974,59:665

    Article  PubMed  CAS  Google Scholar 

  19. - Sandeman T.F. The effects of X irradiation on the human fertility. Brit.J.Radiol., 1966,39:901

    Article  PubMed  CAS  Google Scholar 

  20. - Schweiguth O. L’avenir des enfants guéris d’un cancer. Arch.Fr.Pediatr., 1985,42:3

    Google Scholar 

  21. - Sherins R.J., Olweny C.L.M., Ziegler J.L. Gynaecomastia and gonadal dysfunction in adolescent boys treated with combination chem therapy for Hodgkin’s disease. N.Engl.J.Med., 1978,299:12

    PubMed  CAS  Google Scholar 

  22. - Withehead E., Shalet S.M., Blckledge G., Tood L., Crowther D., Beardwell C.G. The effects of Hodgkin’s disease and combination chemotherapy on gonadal function in the adult male. Cancer 1982,49:418

    Article  Google Scholar 

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Authors and Affiliations

  1. Unité de Médecine de la Reproduction, Service du Pr Ch. Roux-Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012, Paris

    Françoise Grob-Menendez & Dominique Marmor

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  1. Françoise Grob-Menendez
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  2. Dominique Marmor
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présenté aux 4èmes Journées d’Andrologie de l’Hôpital Saint-Antoine le 15 Juin 1992

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Grob-Menendez, F., Marmor, D. Traitements anticancereux et spermatogenese. Moyens de protection. Androl. 2, 97–99 (1992). https://doi.org/10.1007/BF03034683

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Basic and Clinical Andrology

ISSN: 2051-4190