Skip to main content
  • Cancer et Fertilité
  • Published:

Fertilité après radiothérapie

Fertility after radiotherapy

Resume

La radiothérapie fait partie de l'arsenal thérapeutique de la cancérologie. De jeunes patients sont traités pour maladie de Hodgkin ou pour tumeurs testiculaires entraînant des troubles de la fertilité. Notre article se propose de faire la revue de la littérature concernant la fertilité après radiothérapie et d'insister sur l'information des patients ainsi que la prévention.

Abstract

It is now well established that fertility of of young patients is compromised after the radiotherapy treatment for malignant diseases. This paper summarizes the main data concerning the fertility of young patients after radiotherapy treatment. The information of the patients as well as the prevention are the subject of this review.

References

  1. Ash P.: The influence of radiation on fertility in man. Br J Radiol, 1980; 53: 271–278.

    Article  PubMed  CAS  Google Scholar 

  2. Hahn EW, Feingold SM, Simpson L et al.: Recovery of aspermia induced by low dose radiation in seminoma patients. Cancer, 1982; 50: 337–340.

    Article  PubMed  CAS  Google Scholar 

  3. Shapiro E, Kinsella TJ, Makoch RW et al. Effects of fractinated irradiation on endocrine aspects of testicular function. J Clin Oncol, 1985; 3: 1232–1239.

    PubMed  CAS  Google Scholar 

  4. Meistrich ML, Von Beek ME.: Radiation sensitivity of the human testis. Adv Radiat Biol, 1990; 14: 227–268.

    Google Scholar 

  5. Brauner R, Czernichow P, Cramer P et al.: Leydig cell function in children after direct testicular irradiation for acute lymphoblastic leukemia. N Engl J Med, 1983; 309: 25–28.

    PubMed  CAS  Google Scholar 

  6. Horning SJ, Hoppe RT, Kaplan HS et al.: female reproductive potential after treatment for hodgkin disease. N Engl J Med, 1982; 304: 1377–1382.

    Article  Google Scholar 

  7. Thomas PR, Winstantly D, Pecham MJ et al.: reproductive and endocrine function in patients with hodgkin disease. Effects of oophoropexy and irradiation. Br J Cancer, 1976; 33: 226–231.

    PubMed  CAS  Google Scholar 

  8. Fraas BA, Kinsella TJ, Glatstein EJ: Peripheral dose to the testis. The design and use of a practical and effective gonadal shield. Int J Radiat Oncol Biol Phys, 1985; 11: 609–615.

    Google Scholar 

  9. Pedrick TJ, Hoppe RT. Recovery of spermatogenesis following pelvic radiotherapy for hodgkin's disease. Int J Radiat Oncol Biol Phys, 1986; 12: 117–121.

    PubMed  CAS  Google Scholar 

  10. Ray GR, Trueblood HW, Enright LP et al.: Oophoropexy: A means of preserving ovarian function following pelvic meagavoltage radiotherapy for hodgkin's disease. Radiology, 1970; 96: 175–180.

    PubMed  CAS  Google Scholar 

  11. Shull WJ.: Reproductive problems: Fertility teratogenesis and mutagenesis. Arch Envir Health 1984; 39: 207–212.

    Google Scholar 

  12. Marx JL: Lower radiation effect found. Science, 1988; 241: 1286.

    Article  PubMed  CAS  Google Scholar 

  13. Neel JV.: Genetic effects of atomic bombs. Science, 1981, 213: 1205.

    Article  PubMed  CAS  Google Scholar 

  14. Neel JV, Lewis SE.: The comparative radiation genetics of humans and mice. Ann Rev Genet, 1990; 24: 327–362.

    Article  PubMed  CAS  Google Scholar 

  15. Russel WL, Russel LB.: Radiation induced genetic damage in mice. In Progress in nuclear energy, Bugher JC (eds), London, Pergamon Press, 1979; pp. 179–188.

    Google Scholar 

  16. Ronderos A.: Fetal tolerance to radiation. Radiology, 1961; 76: 454–456.

    PubMed  CAS  Google Scholar 

  17. Strauss A.: Irradiation of carcinoma of the cervix uteri during pregnancy. AJR, 1940; 43: 552.

    Google Scholar 

  18. Meiron D, Schenker J.G.: Cancer and male fertility. Human Reprod., 1995, 10: 2017–2022.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fignon, A., Hamamah, S. & Calais, G. Fertilité après radiothérapie. Androl. 6 (Suppl 4), 415–420 (1996). https://doi.org/10.1007/BF03034462

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03034462

Mots clés

Key Words